The Chicago White Sox can’t break through despite “good odds” in a 4-0 loss to the Baltimore Orioles.

The Chicago White Sox had a good history on their side against the Baltimore Orioles in the recent past, but they never had to face Adley Ratchman.

Orioles rookie catcher had the number of Sox starter Johnny Cueto Thursday night, tagging him for a two-run homer in the fourth and an RBI double two innings later to send the Sox to a 4-0 loss in Guaranteed Rate Field.

Rutchman’s three RBIs were the most in his career – he had all four in his first 26 games.

“He had a big night,” Sox manager Tony La Russa said. “Let’s see if we can make some adjustments, silence him.

Cueto threw 5 ⅓ innings, allowed seven hits, including a two-point homer for Rutchman, and hit seven.

The Sox have won eight in a row against the Orioles since May 1, 2019. But they went 1 of 9 with runners in scoring position and left 11 on base.

“I would say that we should win the game when you have nine hits and a lot of difficult outs – you have to mark something, right?” La Russa said. “So we hit the ball hard and couldn’t break through.”

Added catcher Sebi Zavala, who had two doubles: “We had three, four balls that hit pretty well and we thought we had a good chance to get off the yard or at least get off the wall. They just died there.”

One of the highlights for the Sox was the debut of Lenin Sosa in the big leagues, which made a lasting impression on the infielder: “Go out onto the field and see the crowd, the stadium, the fans. I have never played in such a stadium.

“It was pretty amazing.”

The Orioles thought they had grabbed an early lead on Trey Mancini’s potential RBI double in the third inning, but Cedric Mullins was tagged, sliding into the home. The Orioles issued the challenge, believing that the left field relay from AJ Pollock to Tim Anderson and Zavala came too late, but the call was upheld.

In the fourth, Ryan Mountcastle doubled up in the center to move into third due to an error by Leuri Garcia. Rutchman made the Sox pay for this mistake with a two-way homer.

Gavin Sheets, who played his first major tournament game since June 9, gave the Sox hope for a late-half brace, but right fielder Austin Hayes threw him out at home after a Leuri Garcia single.

Sheets followed Jake Burger’s double in the sixth inning with a walk and pursued Orioles starter Dean Kremer, but reliever Felix Bautista eliminated Zavala.

Sheets worked out a 3-0 score in the eighth, but the drama ended with a relegation to the warning lane in midfield.

“He plays well with bats. Very good,” La Russa said.

Injuries forced the Sox to reshuffle their roster before the start of the series.

Anderson, who turned 29 on Thursday, started with a reserve shortstop. Danny Mendik out for the season with a torn anterior cruciate ligament in the right knee. Anderson went 1-for-5 with two strikeouts.

La Russa decided to replace right fielder Adam Engel, who went to the 10-day IL with a right hamstring strain, with Sheets and left Andrew Vaughn at first base.

Luis Robert had a leg problem during Wednesday’s game against the Toronto Blue Jays, so La Russa decided to mount him and put Leuri Garcia in center.

“This is baseball. It’s part of the game,” Cueto said of all the injuries. “I think you should be like a horse – just keep moving forward.”

The Sox’ original plan for Sosa was for him to debut sometime during a four-game weekend home game against the Orioles, but not on Thursday. But Josh Harrison was rocked after being hit by a ball late in the fifth and Sosa replaced him with a second in the sixth. Sosa scored in his first career at-bat and then went ninth on nine at-bats.

“I thought his first fight was okay,” La Russa said. “I think his second at-bat was one of the highlights of the evening. We then competed. He drew a walk, fouled on a couple of difficult pitches. I thought it was very impressive.

“He has all the qualities of a good striker.”

Harrison had a bruised right triceps and the X-ray was negative. He is day by day.

“He has a big old knot on the back of his right throwing arm,” La Russa said. “It was kind of a way to get hit.”

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